UK Free Shipping Semaglutide 2mg 5mg 10mg Peptides Powder GLP-1

Semaglutide 2mg 5mg 10mg Peptides Powder GLP-1

is a successfully marketed single molecule bifunctional peptide that can simultaneously activate GLP-1R and GIPR. Tilposide is composed of 39 amino acids, which are acylated at the C-terminal and bind to the C20 fatty acid moiety through the spacer region of Lys20. Its half-life is 116.7 hours. The affinity between Tilposide and GLP-1R is higher than GLP-1, and its cAMP activation activity is significantly lower. The affinity between tilposide and GIPR is significantly lower than GIP, and its cAMP activity is roughly equal to that of GIP.
The GLP-1 receptor is widely distributed in multiple organs or tissues throughout the body, including the central nervous system, gastrointestinal tract, cardiovascular system, liver, adipose tissue, muscles, etc. By activating the GLP-1 receptor, it can stimulate and enhance insulin secretion, inhibit glucagon secretion, delay gastric emptying, inhibit appetite, increase satiety, and achieve effects such as reducing blood sugar and weight loss. Therefore, in addition to weight loss, Lilalutide and Smeglutide are more used for blood glucose control in type 2 diabetes (T2DM).