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GLP-1 drugs  currently belong to the well-deserved category of "star drugs".
The application for registration of weight-loss indications for is based on the results of 26 clinical studies, including the SURMOUNT series. The common primary endpoint results showed that at 52 weeks of treatment, the average percentage change in body weight from baseline was -14.4% in the 10mg and 15mg treatment groups of , which were superior to the placebo group (-2.4%); The proportion of patients who achieved weight loss of ≥ 5% in the group (10mg, 91.4%; 15mg, 92.7%) was superior to the placebo group (29.4%).
Liraglutide and Semaglutide are both glucagon like peptide-1 (GLP-1) receptor agonists.

Existing research has shown that in comparison with the hypoglycemic effect of smegliptin, reduced the glycated hemoglobin of the subjects by an average of 2.0-2.3%, while semaglutide decreased by an average of 1.9%; In terms of weight loss, resulted in an average weight loss of 17 to 25 pounds in participants, while smeglutide was 13 pounds. exhibits superior levels of hypoglycemic and lipid-lowering properties compared to semaglutide.